Natesan Mani

Welcome to my personal website!

About Me

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Hello! I'm a PhD student in Chemical Engineering, working in the intersection of computational modelling, biophysics and proteomics. My research has focused on applying Molecular Dynamics (MD) to study protein motions, with an emphasis on studying viral spike protein and in antibody design

My thesis focuses on the dynamics of viral spike proteins and how changes in the protein structure, glycosylation profile etc, can impact the overall allostery and function of the Spike protein

During my internship at Prescient Design, Genentech, I worked with Jen Hofmann to design a workflow that can predict high-concentration properties of antibodies. This project leveraged the power of Coarse-Grained simulations in predicting physiological properties

At Amgen, I designed antibodies that have a higher immune response by modifying the glycosylation sites on the Fc domain and performing atomistic MD to understand the structural underpinnings of binding.

Outside of work, you can usually find me in the gym, exploring cafes and pubs in the Boston area, hiking and exploring National Parks (currently 15/63)

You can find my latest resume on this site! Reach out to me to discuss potential opportunities, share ideas about drug discovery or the best hiking spots in the country!

Education